With the rapid growth of digitalization around the world, data governance is urgent for development practitioners who design and implement digital investments, especially those who manage personal or sensitive data. Responsible data governance refers to the application of transparent, inclusive, and rights-respecting data oversight to improve development outcomes and reduce the risk of data misuse. The Responsible Data Governance for Digital Development reference document highlights key considerations for development practitioners and implementing partners who design and implement data-rich activities in USAID programming. The document is intended as a resource to support learning and advance knowledge of responsible data governance principles for consideration in international development and humanitarian assistance.